Structure of PDB 5ost Chain A

Receptor sequence
>5ostA (length=762) Species: 858215 (Thermoanaerobacterium xylanolyticum LX-11) [Search protein sequence]
HKIDIPDSAWTIGIGEKFKNAGHPNVKYPMIDDSYVQGAPLGGFGAGTIG
RTYNGGFSRWHLEIGKNKYTTVYANQFSVFQKVEGNKDGVAQVLYAGEPG
YLSSWKWDYPKESGMYYALYPNSWYTYTNKDLPVQLAVKQFSPIIPYNYK
ETSYPVAVFKWTAYNPTNKNVDVSIMFTWQNMIGFFGKQVNVNSGNFNKI
IKDKSKDSEIVAAVMGNISNDNEEWNGEYSIGVKKVPGVDISYKAKFVTT
GDGSDLWHEFSKNGILDNKDDETPTKQDGIGSAIAVNFKLQPGQTIEVPF
ALSWDLPIMKFGGGDKWYKMYTKYFGKNGKNSFAILKEALNNYQKWEKMI
DDWQKPILSNKSKPDWYKTALFNELYYLADGGTAWENGKVGERTNNMFGL
LECFDYNYYETLDVRFYGSFPLVMLWPDIEKQVMRQFADTINVQDSSEFK
VGSNGAMAVKKVQGMIPHDLGSSYALPWIKINAYDWQNPNIWKDLNSKYV
LLVYRDYVLTGKTDKEFLKYTWKSVKTALDKLKEMDKDNDGIPDNEGIPD
QTYDTWSMKGTSAYCGSLWLAALKAAQEIGKVLKDNEAYIKYNEWYKIAQ
QNFEKELWNGEYYNFDTESDHKDSIMADQLAGQWYADILRLGDILPKDHV
QKALKKIYEFNVMKFENGKMGAVNGMRPDGIVDESDIQAQEVWTGVTYAL
ASFMKYRGMTEEAYNTAYGVYKMTYDKSGKGYWFRTPEAWTKDGNYRASM
YMRPLSIWSMEV
3D structure
PDB5ost Gluco-1 H-imidazole: A New Class of Azole-Type beta-Glucosidase Inhibitor.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.45: glucosylceramidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D575 D577 D579 I581 D583 D536 D538 D540 I542 D544
BS02 AEZ A E441 Y445 D452 H507 Y523 T591 D593 E777 R786 E402 Y406 D413 H468 Y484 T552 D554 E738 R747 MOAD: Kd=27.3uM
PDBbind-CN: -logKd/Ki=4.56,Kd=27.3uM
Gene Ontology
Molecular Function
GO:0004348 glucosylceramidase activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0008422 beta-glucosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006680 glucosylceramide catabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ost, PDBe:5ost, PDBj:5ost
PDBsum5ost
PubMed29601200
UniProtF6BL85

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