Structure of PDB 5oq5 Chain A

Receptor sequence
>5oq5A (length=265) Species: 9606 (Homo sapiens) [Search protein sequence]
VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRCPENIKKE
ICILKMLNHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEP
DAQRFFHQLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADFGLATVF
RYNNRERLLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGE
LPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARIT
IPDIKKDRWYNKPLK
3D structure
PDB5oq5 Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).
ChainA
Resolution1.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D130 K132 H134 N135 D148 T170
Catalytic site (residue number reindexed from 1) D125 K127 H129 N130 D143 T165
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4K4 A V23 A36 A87 S88 G89 G90 L137 V21 A34 A82 S83 G84 G85 L132 MOAD: Ki=0.02uM
PDBbind-CN: -logKd/Ki=7.70,Ki=0.0200uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5oq5, PDBe:5oq5, PDBj:5oq5
PDBsum5oq5
PubMed29023112
UniProtO14757|CHK1_HUMAN Serine/threonine-protein kinase Chk1 (Gene Name=CHEK1)

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