Structure of PDB 5ops Chain A

Receptor sequence
>5opsA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
VPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVNIKKEICILKML
NHENVIKFYGHRREGNIQYLFMELASGGSLFDRIEPDIGMPEPDAQRFFH
QLMAGVVYLHGIGITHRDIKPHNLLLDERDNLKIADYSLATVFRYNNRER
LLNKMCGTLPYVAPELLKRREFHAEPVDVWSCGIVLTAMLAGELPWDQPS
DSCQEYSDWKEKKTYLNPWKKIDSAPLALLHKILVENPSARITIPDIKKD
RWYNKPLK
3D structure
PDB5ops Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D130 K132 H134 N135 D148 T170
Catalytic site (residue number reindexed from 1) D118 K120 H122 N123 D136 T158
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 A3Q A L15 V23 A36 M84 E85 A87 L137 L13 V21 A34 M72 E73 A75 L125 MOAD: Ki=0.863uM
PDBbind-CN: -logKd/Ki=5.06,Ki=8.63uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ops, PDBe:5ops, PDBj:5ops
PDBsum5ops
PubMed29023112
UniProtO14757|CHK1_HUMAN Serine/threonine-protein kinase Chk1 (Gene Name=CHEK1)

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