Structure of PDB 5ol0 Chain A

Receptor sequence
>5ol0A (length=283) Species: 5671 (Leishmania infantum) [Search protein sequence]
APHQEHVLGEPTLEGLAHYIREKNVRRILVLVGAGASVAAGIPDFRSPDT
GIYANLGKYNLEDPTDAFSLTLLREKPEIFYSIARELNLWPGHFQPTAVH
HFIRLLQDEGRLLRCCTQNIDGLEKAAGVSPELLVEAHGSFAAAACIECH
TPFSIEQNYLEAMSGTVSRCSTCGGIVKPNVVFFGENLPDAFFDALHHDA
PIAELVIIIGTSMQVHPFALLPCVVPKSVPRVVMNRERVGGLLFRFDVCR
DVLFRGDCQENVVTLAEYLGLSEALAKRMRLSD
3D structure
PDB5ol0 The crystal structure of the Leishmania infantum Silent Information Regulator 2 related protein 1: Implications to protein function and drug design.
ChainA
Resolution1.99 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P49 D50 F51 R52 N125 D127 H144
Catalytic site (residue number reindexed from 1) P43 D44 F45 R46 N119 D121 H138
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 peptide A H144 V188 F189 F190 G191 E192 N193 L194 F199 V221 H222 P223 H138 V182 F183 F184 G185 E186 N187 L188 F193 V215 H216 P217
BS02 ZN A C152 C155 C176 C179 C146 C149 C170 C173
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5ol0, PDBe:5ol0, PDBj:5ol0
PDBsum5ol0
PubMed29543820
UniProtA0A6L0XH39

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