Structure of PDB 5ojo Chain A

Receptor sequence
>5ojoA (length=265) Species: 7955 (Danio rerio) [Search protein sequence]
SDLTAFREHFAKAKHIAIITGAGVSAESGVPTFRGPGGFWRKWQAQDLAT
PEAFSRDPSLVWEFYHYRREVMRSKMPNPAHLAIAECEARLGQQGRSVVI
ITQNIDELHHRAGSKHVYEIHGSLFKTRCMSCGEVKANHKSPICPALDGK
GAPDPNTKEARIPVELLPRCERKSCNGLLRPHVVWFGETLDSDILTAVER
ELEKCDLCLVVGTSSIVYPAAMFAPQVASRGVPVAEFNMECTPATQRFKY
HFEGPCGSTLPPALE
3D structure
PDB5ojo Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.
ChainA
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P64 T65 F66 R67 N137 D139 H154
Catalytic site (residue number reindexed from 1) P31 T32 F33 R34 N104 D106 H121
Enzyme Commision number 2.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R67 V217 F219 E221 T222 L223 Y251 M255 R34 V184 F186 E188 T189 L190 Y218 M222
BS02 ZN A C162 C165 C203 C208 C129 C132 C170 C175
BS03 MAH A R101 H154 V217 R68 H121 V184
BS04 MAH A R101 F219 R68 F186
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5ojo, PDBe:5ojo, PDBj:5ojo
PDBsum5ojo
PubMed29138502
UniProtQ6DHI5|SIR5_DANRE NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=sirt5)

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