Structure of PDB 5ojn Chain A

Receptor sequence
>5ojnA (length=272) Species: 8364 (Xenopus tropicalis) [Search protein sequence]
HMVPACPPPNPHQVEQLQDFVSQSQRLFVMTGAGISTESGIPDYRSEGVG
LYSRTERRPIQHSEFVQSQAARRRYWARNFVGWPSFSSHEPNSAHVNLCK
WERAGRLHWLVTQNVDALHTKAGQCRLSELHGCTHRVICLGCQTVTKRSE
LQERFLNLNPSWNELTDEQVSDFQVPACTKCGGILKPQVTFFGDTVNRGF
VFSIYEQMKQADAMLIVGSSLQVYSGYRFALNAKELHLPIAILNIGPTRA
DHLAKVKVSARCGDVLPHILLQ
3D structure
PDB5ojn Crystal structures of the mitochondrial deacylase Sirtuin 4 reveal isoform-specific acyl recognition and regulation features.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P71 D72 Y73 R74 N143 D145 H160
Catalytic site (residue number reindexed from 1) P42 D43 Y44 R45 N114 D116 H131
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C168 C171 C219 C222 C139 C142 C178 C181
BS02 9X8 A P33 G61 A62 G63 T66 E67 D72 Y73 R74 S75 Q142 H160 G259 S260 S261 V264 N285 I286 G287 R302 C303 P4 G32 A33 G34 T37 E38 D43 Y44 R45 S46 Q113 H131 G218 S219 S220 V223 N244 I245 G246 R261 C262
Gene Ontology
Molecular Function
GO:0034979 NAD-dependent protein lysine deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5ojn, PDBe:5ojn, PDBj:5ojn
PDBsum5ojn
PubMed29138502
UniProtQ28CB4

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