Structure of PDB 5ojg Chain A

Receptor sequence
>5ojgA (length=260) Species: 6239 (Caenorhabditis elegans) [Search protein sequence]
MPSNCRRFEGKVAIVTAATKGIGLAIAERLLDEGASVVIGSRNQKNVDEA
IEYLKNKGLTKVAGIAGHIASTDDQKKLVDFTLQKFGKINILVNNHGINP
AFGHILEVSDQVWDKLFEVNVKAGFQMTKLVHPHIAKEGGGAIIFNASYS
AYKSPPGIAAYGVTKTTLVGLTRALAMGLAKDNIRVNGIAPGVIKTKMSQ
VLWDGGEDAEKELTDIQEIALGRLGVPDDCAGTVAYLASDDSSYITGEMI
IIAGGVQARL
3D structure
PDB5ojg Crystal structure and catalytic characterization of the dehydrogenase/reductase SDR family member 4 (DHRS4) from Caenorhabditis elegans.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G21 S148 Y161 K165
Catalytic site (residue number reindexed from 1) G21 S148 Y161 K165
Enzyme Commision number 1.1.1.184: carbonyl reductase (NADPH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A A17 T19 G21 I22 S41 R42 N43 N46 I69 N95 H96 G97 N146 S148 Y161 K165 P191 I194 T196 M198 A17 T19 G21 I22 S41 R42 N43 N46 I69 N95 H96 G97 N146 S148 Y161 K165 P191 I194 T196 M198
BS02 BUO A S148 Y161 S148 Y161
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004090 carbonyl reductase (NADPH) activity
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:5ojg, PDBe:5ojg, PDBj:5ojg
PDBsum5ojg
PubMed29151266
UniProtG5EGA6|DHRS4_CAEEL Dehydrogenase/reductase SDR family member 4 (Gene Name=dhrs-4)

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