Structure of PDB 5ohp Chain A

Receptor sequence
>5ohpA (length=315) Species: 9606 (Homo sapiens) [Search protein sequence]
KGLVPGLVNLGNTAFMNSLLQGLSACPAFIRWLEEFTSQYSHQYLSLTLL
HLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITS
SLEDERDGSGSHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSI
PAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEHQRTTFVKQLKLGK
LPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEDLSMDEYKYHSNASTYLFR
LMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQ
EVLSSSAYLLFYERV
3D structure
PDB5ohp Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N72 A77 H452 S477
Catalytic site (residue number reindexed from 1) N9 A14 H265 S290
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C234 C237 C284 C287 C129 C132 C179 C182
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5ohp, PDBe:5ohp, PDBj:5ohp
PDBsum5ohp
PubMed28945249
UniProtQ70CQ3|UBP30_HUMAN Ubiquitin carboxyl-terminal hydrolase 30 (Gene Name=USP30)

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