Structure of PDB 5ofb Chain A

Receptor sequence
>5ofbA (length=534) Species: 9606 (Homo sapiens) [Search protein sequence]
MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDI
YAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKLTQIGQYGNGLKSG
SMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREP
VTDNVEKFAIETELIYKYSPFRTEEEVMTQFMKIPGDSGTLVIIFNLKLM
DNGEPELDIISNPRDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFI
HGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAR
EAESKARTLEVRLGGDLTRDSRVMLRQVQNRAITLRREADVKKRIKEAKQ
RALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMAC
GGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIA
QRGIIKFWDEFGYLSANWNQPPSSELRYKRRRAMEIPTTIQCDLCLKWRT
LPFDTWVCSMNPDPEQDRCEASEQKQKVPLGTFR
3D structure
PDB5ofb Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.
ChainA
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C499 C502 C525 C536 C492 C495 C508 C519
BS02 ATP A N39 A43 M73 K86 G98 Q99 Y100 G101 N102 G103 L104 K105 T197 K427 N39 A43 M73 K86 G91 Q92 Y93 G94 N95 G96 L97 K98 T190 K420
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding

View graph for
Molecular Function
External links
PDB RCSB:5ofb, PDBe:5ofb, PDBj:5ofb
PDBsum5ofb
PubMed29440755
UniProtQ9Y6X9|MORC2_HUMAN ATPase MORC2 (Gene Name=MORC2)

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