Structure of PDB 5odh Chain A

Receptor sequence

>5odhA (length=652) Species: 523845 (Methanothermococcus thermolithotrophicus DSM 2095) [Search protein sequence]

EEPRIGVYVCHCGVNIGGTVDCPDVTEFAKTLKNVVVARDYKYMCADPGQ
EMIKKDIKEHNLNRVVVAACSPRLHEPTFRRCVAEAGLNPFLFEFANIRE
HCSWVHMHEKEKATEKAKDLVRMAVAKARLLEPLEFIKVGVTQRALVIGG
GVAGIQTALDLGDMGFETILVEKTPSVGGRMAQLDKTFPTNDCSICILAP
KMVDVAKHPNVKLYAYSEVVDVQGYVGNFKVKIMKKARYIDETKCTGCGQ
CSEVCPIDVPNEFDMGIGMRKAIYKPFPQAVPAKYTIDKEHCIECGLCAK
VCGPNAIDFDQEPEIIEAEVGTIICAIGYDAFDPTVREEYGYGVYDNVVT
ALELERMINASGPTGGKVIRLSDGQKPKRIAFIQCVGSRDAKVGNKYCSN
VCCMYAMKNSQLIKEKSPDTEIDIYYMDIRAFSKGYEEFYERSAKQYGIK
FMRGRPSQVIEDPETGNLVVRAEDTLLGEILEKEYDLVVLSVGMVPTKSA
DEVQKILGISRTPDQFFMEAHPKLRPVDTATDGVYLAGACQGPKDIPASV
AQGSAAASRAAIPLAKGEVEVEPIIASVDAEICGGCGVCVKQCPYGAPRL
VEKDGKVVAEVISALCKGCGTCPAGCPSGALEQDHFKTIQLFKQIEGMFR
DT

3D structure

PDB

5odh Methanogenic heterodisulfide reductase (HdrABC-MvhAGD) uses two noncubane [4Fe-4S] clusters for reduction.

Chain

Resolution

2.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.8.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	SF4	A	C386 C399 N401 C403 C404 R431	C385 C398 N400 C402 C403 R430
BS02	SF4	A	C246 C249 C252 C303 P305	C245 C248 C251 C302 P304
BS03	SF4	A	C256 P257 A273 C293 I294 C296 G297 C299	C255 P256 A272 C292 I293 C295 G296 C298
BS04	SF4	A	C11 C13 C46 A70 C71 H76	C10 C12 C45 A69 C70 H75
BS05	SF4	A	C594 C617 K618 C620 G621 C623	C593 C616 K617 C619 G620 C622
BS06	SF4	A	C584 C587 C590 A610 C627 S629 L632	C583 C586 C589 A609 C626 S628 L631
BS07	FAD	A	I149 G150 G151 G152 V153 A154 E173 K174 G180 R181 L185 T188 F189 I328 G329 Y330 E356 Y406 K409 S500 G539 K545 D546 I547	I148 G149 G150 G151 V152 A153 E172 K173 G179 R180 L184 T187 F188 I327 G328 Y329 E355 Y405 K408 S499 G538 K544 D545 I546

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

View graph for
Molecular Function

External links

PDB	RCSB:5odh, PDBe:5odh, PDBj:5odh
PDBsum	5odh
PubMed	28818947
UniProt	A0A2D0TCB9

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