Structure of PDB 5odc Chain A

Receptor sequence

>5odcA (length=653) Species: 523845 (Methanothermococcus thermolithotrophicus DSM 2095) [Search protein sequence]

EEPRIGVYVCHCGVNIGGTVDCPDVTEFAKTLKNVVVARDYKYMCADPGQ
EMIKKDIKEHNLNRVVVAACSPRLHEPTFRRCVAEAGLNPFLFEFANIRE
HCSWVHMHEKEKATEKAKDLVRMAVAKARLLEPLEFIKVGVTQRALVIGG
GVAGIQTALDLGDMGFETILVEKTPSVGGRMAQLDKTFPTNDCSICILAP
KMVDVAKHPNVKLYAYSEVVDVQGYVGNFKVKIMKKARYIDETKCTGCGQ
CSEVCPIDVPNEFDMGIGMRKAIYKPFPQAVPAKYTIDKEHCIECGLCAK
VCGPNAIDFDQEPEIIEAEVGTIICAIGYDAFDPTVREEYGYGVYDNVVT
ALELERMINASGPTGGKVIRLSDGQKPKRIAFIQCVGSRDAKVGNKYCSN
VCCMYAMKNSQLIKEKSPDTEIDIYYMDIRAFSKGYEEFYERSAKQYGIK
FMRGRPSQVIEDPETGNLVVRAEDTLLGEILEKEYDLVVLSVGMVPTKSA
DEVQKILGISRTPDQFFMEAHPKLRPVDTATDGVYLAGACQGPKDIPASV
AQGSAAASRAAIPLAKGEVEVEPIIASVDAEICGGCGVCVKQCPYGAPRL
VEKDGKVVAEVISALCKGCGTCPAGCPSGALEQDHFKTIQLFKQIEGMFR
DTA

3D structure

PDB

5odc Methanogenic heterodisulfide reductase (HdrABC-MvhAGD) uses two noncubane [4Fe-4S] clusters for reduction.

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.8.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	FAD	A	I149 G150 G152 V153 A154 E173 K174 G180 R181 L185 T188 F189 A327 I328 G329 Y330 A352 L353 E356 Y406 K409 S500 G539 K545 D546 I547	I148 G149 G151 V152 A153 E172 K173 G179 R180 L184 T187 F188 A326 I327 G328 Y329 A351 L352 E355 Y405 K408 S499 G538 K544 D545 I546
BS02	SF4	A	C11 C13 C46 A70 C71 H76	C10 C12 C45 A69 C70 H75
BS03	SF4	A	C246 T247 G248 C249 G250 C252 Y286 C303	C245 T246 G247 C248 G249 C251 Y285 C302
BS04	SF4	A	C256 P257 C293 E295 C296 G297 C299	C255 P256 C292 E294 C295 G296 C298
BS05	SF4	A	Q385 C386 R390 C399 S400 N401 C403 C404 R431	Q384 C385 R389 C398 S399 N400 C402 C403 R430
BS06	SF4	A	C584 C587 G588 V589 C590 A610 C627 S629 L632	C583 C586 G587 V588 C589 A609 C626 S628 L631
BS07	SF4	A	A577 C594 C617 K618 C620 G621 C623	A576 C593 C616 K617 C619 G620 C622

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0051539	4 iron, 4 sulfur cluster binding

View graph for
Molecular Function

External links

PDB	RCSB:5odc, PDBe:5odc, PDBj:5odc
PDBsum	5odc
PubMed	28818947
UniProt	A0A2D0TCB9

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