Structure of PDB 5od2 Chain A

Receptor sequence
>5od2A (length=456) Species: 243232 (Methanocaldococcus jannaschii DSM 2661) [Search protein sequence]
EIKKFIETIKGTKLFTAYNTNVDAIKYLKDEDVQKLVDEFNHKDIIERME
EYPRIIEEPLDFVARLVHSIKTGKPAEVPIKDDKKLHEWFDRIKYDEERM
GGQAGIVSNLMATLQIDKIIVYTPFLSKKQAEMFVDYDNLLYPLVENGNL
VLKKVREAYRDDPIKINRIFEFKKGLKFKLNGEEITAKQSTRFIVASRPE
ALRIEIKDDVRKFLPKIGEAVDCAFLSGYQAIKEEYRDGKTAKYYFERAE
EDIKLLKKNKNIKTHLEFASISNIEIRKMVVDYILSNVESVGMDETEIAN
VLHILGYDELSNNILKDSFIEDVIEGAKILLDKFKNLEVVQVHTIYYILF
VCRADNPLSKEELEECLEFSTILASTKAKLGNIRAIDDLHEGLKIPHNKY
GDLLKEIAEKFNDNNYKIALSPSRYVEKPKSTVGLGDTISSGAFVYYVSL
LNKKRM
3D structure
PDB5od2 Crystal structure of ADP-dependent glucokinase from Methanocaldococcus jannaschii in complex with 5-iodotubercidin reveals phosphoryl transfer mechanism.
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.146: ADP-specific phosphofructokinase.
2.7.1.147: ADP-specific glucose/glucosamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A D28 E82 G106 G107 Q108 I111 N172 D442 D23 E77 G101 G102 Q103 I106 N167 D437
BS02 5ID A T349 A383 S428 Y430 V431 P434 L440 I444 T344 A378 S423 Y425 V426 P429 L435 I439 MOAD: Ki=0.74mM
BS03 PO4 A R197 G439 G441 D442 R192 G434 G436 D437
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008443 phosphofructokinase activity
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0043843 ADP-specific glucokinase activity
GO:0043844 ADP-specific phosphofructokinase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006000 fructose metabolic process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:5od2, PDBe:5od2, PDBj:5od2
PDBsum5od2
PubMed29352744
UniProtQ58999|K6PF_METJA Bifunctional ADP-specific glucokinase/phosphofructokinase (Gene Name=pfkC)

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