Structure of PDB 5oc8 Chain A

Receptor sequence
>5oc8A (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
IPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYD
EKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
3D structure
PDB5oc8 Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201.
ChainA
Resolution1.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9QW A L54 G58 I61 M62 Y67 Q72 F86 V93 H96 I99 Y100 L36 G40 I43 M44 Y49 Q54 F68 V75 H78 I81 Y82 BindingDB: IC50=0.23nM,Ki=0.210000nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:5oc8, PDBe:5oc8, PDBj:5oc8
PDBsum5oc8
PubMed30135191
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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