Structure of PDB 5oai Chain A

Receptor sequence
>5oaiA (length=97) Species: 9606 (Homo sapiens) [Search protein sequence]
MQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRL
YDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQ
3D structure
PDB5oai A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53wtosteosarcoma cells.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B5K A L54 G58 I61 F86 V93 H96 I99 L38 G42 I45 F70 V77 H80 I83 MOAD: Ki=0.1uM
PDBbind-CN: -logKd/Ki=5.15,Kd=7uM
BindingDB: Ki=0.13nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5oai, PDBe:5oai, PDBj:5oai
PDBsum5oai
PubMed30715803
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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