Structure of PDB 5o9w Chain A

Receptor sequence
>5o9wA (length=356) Species: 3469 (Papaver somniferum) [Search protein sequence]
SNAMEKAKLMKLGNGMEIPSVQELAKLTLAEIPSRYVCALLPMGETIPVI
DIENLLSPEPIIGKLELDRLHFACKEWGFFQVVNHGVDASLVDSVKSEIQ
GFFNLSMDEKTKYEQEDGDVEGFGQGFIESEDQTLDWADIFMMFTLPLHL
RKPHLFSKLPVPLRETIESYSSEMKKLSMVLFNKMEKALQVQAAEIKGMS
EVFIDGTQAMRMNYYPPCPQPNLAIGLTSHSDFGGLTILLQINEVEGLQI
KREGTWISVKPLPNAFVVNVGDILEIMTNGIYHSVDHRAVVNSTNERLSI
ATFHDPSLESVIGPISSLITPETPALFKSGSTYGDLVEECKTRKLDGKSF
LDSMRI
3D structure
PDB5o9w Crystal structure of thebaine 6-O-demethylase from the morphine biosynthesis pathway.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.31: thebaine 6-O-demethylase.
2.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AKG A N221 Y223 L235 H238 L247 H295 R305 S307 N213 Y215 L227 H230 L239 H287 R297 S299
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0030782 (S)-tetrahydroprotoberberine N-methyltransferase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0102802 thebaine 6-O-demethylase activity
Biological Process
GO:0009820 alkaloid metabolic process
GO:0032259 methylation
GO:0097295 morphine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5o9w, PDBe:5o9w, PDBj:5o9w
PDBsum5o9w
PubMed29408320
UniProtD4N500|DIOX1_PAPSO Thebaine 6-O-demethylase (Gene Name=T6ODM)

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