Structure of PDB 5o9u Chain A

Receptor sequence

>5o9uA (length=393) Species: 9606 (Homo sapiens)

GPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLP
QGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRP
PGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKK
LRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNP
RKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLL
TRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTL
PSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNAL
DLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ

3D structure

• PDB: 5o9u Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern.
• Chain: A
• Resolution: 1.85 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	V181 D183 D185 F190 T282 Y296 H298 S300 F311 S312 Y327 I469 G470 D471 G472 N473	V78 D80 D82 F87 T179 Y193 H195 S197 F208 S209 Y224 I366 G367 D368 G369 N370
BS02	COA	A	Y117 Q118 F119 W120 Y180 V181 L248 V250 R255 S256 R258 A260 P261 A283	Y14 Q15 F16 W17 Y77 V78 L145 V147 R152 S153 R155 A157 P158 A180

Gene Ontology

Molecular Function

• GO:0004379 glycylpeptide N-tetradecanoyltransferase activity

Biological Process

• GO:0006499 N-terminal protein myristoylation

External links

• PDB: RCSB:5o9u, PDBe:5o9u, PDBj:5o9u
• PDBsum: 5o9u
• PubMed: 29892081
• UniProt: P30419|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)