Structure of PDB 5o97 Chain A

Receptor sequence
>5o97A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5o97 Crystal structure of human BRD4(1) bromodomain in complex with JRMBR4106
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9OE A W81 P82 V87 L92 C136 N140 I146 W40 P41 V46 L51 C95 N99 I105 BindingDB: IC50=22000nM
External links
PDB RCSB:5o97, PDBe:5o97, PDBj:5o97
PDBsum5o97
PubMed
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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