Structure of PDB 5o83 Chain A

Receptor sequence
>5o83A (length=794) Species: 10090 (Mus musculus) [Search protein sequence]
VKKLINSQISLLIGKGLHEFDSLRDPEVNDFRTKMRQFCEEAAAHRQQLG
WVEWLQYSFPLQLEPNRALLVNVKFEGSEESFTFQVSTKDMPLALMACAL
RKKATVFRQQPEEYALQVNGRHEYLYGNYPLCHFQYICSCLHSLTPHLTM
VHSSSILAMRDEQSNWSLEQPFSILIEGRKVNADMKLVVQAGLFHGNEML
CKTVSSSECSEPVWEFDISVCDLPRMARLCFALYAVDCPIAWANLMLFDY
KDQLKTGERCLYMWPSVLNPAGTVRGNPNTESAAALVIYLPEVAPVYFPA
LEKILELLYEHEKDLVWKMRHEVQEHFPEALARLLLVTKWNKHEDVAQML
YLLCSWPELPVLSALELLDFSFPDCYVGSFAIKSLRKLTDDELFQYLLQL
VQVLKYESYLDCELTKFLLGRALANRKIGHFLFWHLRSEMHVPSVALRFG
LIMEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKVSSQKTTKPQTKEMM
HMCMRQETYMEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSS
EEAGSAGNVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGC
LPTGDRTGLIEVVLHSDTIANIQLNAAFNKDALLNWLKSKNPGEALDRAI
EEFTLSCAGYCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNVPFI
LTYDFVHVIQQGKTNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRA
AGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFNEALRESW
3D structure
PDB5o83 Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors.
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9NQ A M752 P758 W760 K779 D787 I825 V828 M900 I910 D911 M537 P543 W545 K564 D572 I610 V613 M678 I688 D689 PDBbind-CN: -logKd/Ki=7.96,IC50=0.011uM
BindingDB: IC50=101nM
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
Biological Process
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5o83, PDBe:5o83, PDBj:5o83
PDBsum5o83
PubMed28947947
UniProtO35904|PK3CD_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Gene Name=Pik3cd)

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