Structure of PDB 5o7e Chain A

Receptor sequence
>5o7eA (length=380) Species: 1498 (Hathewaya histolytica) [Search protein sequence]
YCPKTYTFDDGKVIIKAGARVEEEKVKRLYWASKEVNSQFFRVYGIDKPL
EEGNPDDILTMVIYNSPEEYKLNSVLYGYDTNNGGMYIEPEGTFFTYERE
AQESTYTLEELFRHEYTHYLQGRYAVPGQWGRTKLYDNDRLTWYEEGGAE
LFAGSTRTSGILPRKSIVSNIHNTTRNNRYKLSDTVHSKYGASFEFYNYA
CMFMDYMYNKDMGILNKLNDLAKNNDVDGYDNYIRDLSSNHALNDKYQDH
MQERIDNYENLTVPFVADDYLVRHAYKNPNEIYSEISEVAKLKDAKSEVK
KSQYFSTFTLRGSYTGGVSKGKLEDQKAMNKFIDDSLKKLDTYSWSGYKT
LTAYFTNYKVDSSNKVTYDVVFHGYLPNEG
3D structure
PDB5o7e Discovery of a Potent Inhibitor Class with High Selectivity toward Clostridial Collagenases.
ChainA
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.3: microbial collagenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H455 H459 E487 H114 H118 E146
BS02 CA A E430 G463 V467 P468 G469 E89 G122 V126 P127 G128
BS03 9NB A M427 Y428 E430 H455 H459 W471 E486 E487 M86 Y87 E89 H114 H118 W130 E145 E146 MOAD: ic50=0.017uM
PDBbind-CN: -logKd/Ki=8.00,IC50=0.010uM
BindingDB: IC50=17nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5o7e, PDBe:5o7e, PDBj:5o7e
PDBsum5o7e
PubMed28820255
UniProtQ46085|COLH_HATHI Collagenase ColH (Gene Name=colH)

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