Structure of PDB 5o5h Chain A

Receptor sequence
>5o5hA (length=112) Species: 9606 (Homo sapiens) [Search protein sequence]
MQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFFT
MKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGGA
VLRQARRQAEKM
3D structure
PDB5o5h Structure-based discovery of selective BRPF1 bromodomain inhibitors.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9LK A F653 V657 P658 Y707 N708 F714 F26 V30 P31 Y80 N81 F87 PDBbind-CN: -logKd/Ki=4.12,IC50>75uM
BindingDB: Kd=>75000nM
BS02 9LK A F653 V657 E661 Y707 F714 F26 V30 E34 Y80 F87 PDBbind-CN: -logKd/Ki=4.12,IC50>75uM
BindingDB: Kd=>75000nM
External links
PDB RCSB:5o5h, PDBe:5o5h, PDBj:5o5h
PDBsum5o5h
PubMed29902720
UniProtP55201|BRPF1_HUMAN Peregrin (Gene Name=BRPF1)

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