Structure of PDB 5o5a Chain A

Receptor sequence
>5o5aA (length=113) Species: 9606 (Homo sapiens) [Search protein sequence]
EMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFF
TMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGG
AVLRQARRQAEKM
3D structure
PDB5o5a Structure-based discovery of selective BRPF1 bromodomain inhibitors.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9LN A I652 E655 V657 P658 E661 C704 Y707 N708 F714 I26 E29 V31 P32 E35 C78 Y81 N82 F88 PDBbind-CN: -logKd/Ki=4.77,Kd=17uM
BindingDB: Kd=17000nM
External links
PDB RCSB:5o5a, PDBe:5o5a, PDBj:5o5a
PDBsum5o5a
PubMed29902720
UniProtP55201|BRPF1_HUMAN Peregrin (Gene Name=BRPF1)

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