Structure of PDB 5o4t Chain A

Receptor sequence
>5o4tA (length=113) Species: 9606 (Homo sapiens) [Search protein sequence]
EMQLTPFLILLRKTLEQLQEKDTGNIFSEPVPLSEVPDYLDHIKKPMDFF
TMKQNLEAYRYLNFDDFEEDFNLIVSNCLKYNAKDTIFYRAAVRLREQGG
AVLRQARRQAEKM
3D structure
PDB5o4t Structure-based discovery of selective BRPF1 bromodomain inhibitors.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9KT A V662 Y707 N708 F714 V36 Y81 N82 F88 PDBbind-CN: -logKd/Ki=3.40,IC50>400uM
BindingDB: IC50=>400000nM
External links
PDB RCSB:5o4t, PDBe:5o4t, PDBj:5o4t
PDBsum5o4t
PubMed29902720
UniProtP55201|BRPF1_HUMAN Peregrin (Gene Name=BRPF1)

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