Structure of PDB 5o3a Chain A

Receptor sequence
>5o3aA (length=108) Species: 9606 (Homo sapiens) [Search protein sequence]
SEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGVHDYHDIIKHPMDL
STVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVF
EFRYAKMP
3D structure
PDB5o3a Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 31P A W370 P371 F372 V376 L381 Y428 N429 H433 V435 M438 W24 P25 F26 V30 L35 Y82 N83 H87 V89 M92
External links
PDB RCSB:5o3a, PDBe:5o3a, PDBj:5o3a
PDBsum5o3a
PubMed29732121
UniProtP25440|BRD2_HUMAN Bromodomain-containing protein 2 (Gene Name=BRD2)

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