Structure of PDB 5o2t Chain A

Receptor sequence
>5o2tA (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
MTEYKLVVVGAVGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGET
CLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQI
KRVKDSEDVPMVLVGNKCDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQ
GVDDAFYTLVREIR
3D structure
PDB5o2t Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.
ChainA
Resolution2.19 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S17 T35 S17 T35
BS02 GSP A G13 V14 G15 K16 S17 A18 F28 V29 D30 T35 G60 N116 K117 D119 S145 A146 G13 V14 G15 K16 S17 A18 F28 V29 D30 T35 G60 N116 K117 D119 S145 A146 MOAD: Kd=3.9nM
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5o2t, PDBe:5o2t, PDBj:5o2t
PDBsum5o2t
PubMed28706291
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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