Structure of PDB 5o2d Chain A

Receptor sequence
>5o2dA (length=189) Species: 9606 (Homo sapiens) [Search protein sequence]
SWEKGSLVSPGGLQMLLVKEGVQNAKTDVVVNSVPLDLVLSRGPLSSSLL
EKAGPELQEELDTVGQGVAVSMGTVLKTSSWNLDCRYVLHVVAPEWRNGS
TSSLKIMEDIIRECMEITESLSLKSIAFPAIGTGNLGFPKNIFAELIISE
VFSFSSSNQLSTLQEVHFLLHPSDHENIQAFSDEFARRA
3D structure
PDB5o2d Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9HH A V1032 F1129 P1130 A1131 I1132 G1133 F1144 I1148 N1178 F1182 V31 F128 P129 A130 I131 G132 F143 I147 N177 F181 PDBbind-CN: -logKd/Ki=5.68,Kd=2.1uM
BindingDB: IC50=900nM,Kd=2100nM
External links
PDB RCSB:5o2d, PDBe:5o2d, PDBj:5o2d
PDBsum5o2d
PubMed28991428
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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