Structure of PDB 5o1o Chain A

Receptor sequence
>5o1oA (length=439) Species: 9606 (Homo sapiens) [Search protein sequence]
RKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKNQIEQLGKKYNINPVS
MDICKQEEKLGFLVAKQDLVISLLPYVLHPLVAKACITNKVNMVTASYIT
PALKELEKSVEDAGITIIGELGLDPGLDHMLAMESIDKAKEVGATIESYI
SYCGGLPAPEHSNNPLRYKFSWSPVGVLMNVMQSATYLLDGKVVNVAGGI
SFLDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGISSAHTLLRGTLRYKGY
MKALNGFVKLGLINREALPNPLTWKQLLCDLVGISPSSEHDVLKEAVLKK
LGGDNTQLEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGPEEKDMI
VMRDSFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLL
DGEIGAKGLMGPFSKEIYGPILERIKAEGIIYTTQSTIK
3D structure
PDB5o1o Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with proline bound.
ChainA
Resolution2.48 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D604
Catalytic site (residue number reindexed from 1) D124
Enzyme Commision number 1.5.1.8: saccharopine dehydrogenase (NADP(+), L-lysine-forming).
1.5.1.9: saccharopine dehydrogenase (NAD(+), L-glutamate-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PRO A D604 R726 D124 R246
External links
PDB RCSB:5o1o, PDBe:5o1o, PDBj:5o1o
PDBsum5o1o
PubMed
UniProtQ9UDR5|AASS_HUMAN Alpha-aminoadipic semialdehyde synthase, mitochondrial (Gene Name=AASS)

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