Structure of PDB 5o0j Chain A

Receptor sequence
>5o0jA (length=453) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
TNWESLYEKALDKVEASIRKVRGVLLAYNTNIDAIKYLKREDLEKRIEKV
GKEEVLRYSEELPKEIETIPQLLGSILWSIKRGKAAELLVVSREVREYMR
KWGWDELRMGGQVGIMANLLGGVYGIPVIAHVPQLSELQASLFLDGPIYV
PTFERGELRLIHPREFRKGEEDCIHYIYEFPRNFKVLDFEAPRENRFIGA
ADDYNPILYVREEWIERFEEIAKRSELAIISGLHPLTQENHGKPIKLVRE
HLKILNDLGIRAHLEFAFTPDEVVRLEIVKLLKHFYSVGLNEVELASVVS
VMGEKELAERIISKDPADPIAVIEGLLKLIKETGVKRIHFHTYGYYLALT
REKGEHVRDALLFSALAAATKAMKGNIEKLSDIREGLAVPIGEQGLEVEK
ILEKEFSLRDGIGSIEDYQLTFIPTKVVKKPKSTVGIGDTISSSAFVSEF
SLH
3D structure
PDB5o0j Structural basis for ADP-dependent glucokinase inhibition by 8-bromo-substituted adenosine nucleotide.
ChainA
Resolution1.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.-
2.7.1.147: ADP-specific glucose/glucosamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8BR A E198 N295 H345 T346 Y347 V431 V432 P435 I441 E194 N291 H341 T342 Y343 V427 V428 P431 I437 MOAD: Kd=16.85uM
PDBbind-CN: -logKd/Ki=4.77,Kd=16.85uM
BS02 8BR A W82 R86 K88 F272 W78 R82 K84 F268 MOAD: Kd=16.85uM
PDBbind-CN: -logKd/Ki=4.77,Kd=16.85uM
BS03 GLC A D37 E91 G114 G115 Q116 H179 D443 D33 E87 G110 G111 Q112 H175 D439
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004340 glucokinase activity
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0043843 ADP-specific glucokinase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5o0j, PDBe:5o0j, PDBj:5o0j
PDBsum5o0j
PubMed29784881
UniProtO58328|GLKA_PYRHO ADP-dependent glucose/glucosamine kinase (Gene Name=glkA)

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