Structure of PDB 5nzm Chain A

Receptor sequence
>5nzmA (length=483) Species: 5664 (Leishmania major) [Search protein sequence]
KSLSAAAQACVKKMRDAKVNEACIRTFIAQHVMVSKGETGSIPDSAIMPV
DSLDALDSLTIECDNAVLQSTVVLKLNGGLGTGMGLCDAKTLLEVKDGKT
FLDFTALQVQYLRQHCSEHLRFMLMDSFNTSASTKSFLKARYPWLYQVFD
SEVELMQNQVPKILQDTLEPAAWAENPAYEWAPPGHGDIYTALYGSGKLQ
ELVEQGYRYMFVSNGDNLGATIDKRVLAYMEKEKIDFLMEVCRRTESDKK
GGHLARQTVYVKGKDGQPDAEKRVLLLRESAQCPKADMESFQDINKYSFF
NTNNLWIRLPVLLETMQEHGGTLPLPVIRNEKTVDSSNSASPKVYQLETA
MGAAIAMFESASAIVVPRSRFAPVKTCADLLALRSDAYVVTDDFRLVLDD
RCHGHPPVVDLDSAHYKMMNGFEKLVQHGVPSLVECKRVTVKGLVQFGAG
NVLTGTVTIENTDSASAFVIPDGAKLNDTTASP
3D structure
PDB5nzm Decoding Allosteric Networks in Biocatalysts: Rational Approach to Therapies and Biotechnologies
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.9: UTP--glucose-1-phosphate uridylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9ET A R248 R373 R243 R368 PDBbind-CN: -logKd/Ki=3.90,IC50=127uM
Gene Ontology
Molecular Function
GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity
GO:0016779 nucleotidyltransferase activity
GO:0070569 uridylyltransferase activity
Biological Process
GO:0005977 glycogen metabolic process
GO:0006011 UDP-glucose metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031981 nuclear lumen
GO:0097014 ciliary plasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nzm, PDBe:5nzm, PDBj:5nzm
PDBsum5nzm
PubMed
UniProtQ4QDU3

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