Structure of PDB 5nv9 Chain A

Receptor sequence
>5nv9A (length=480) Species: 529507 (Proteus mirabilis HI4320) [Search protein sequence]
DFGFINYAVLFGYLAAMLLVGVYFSKRQKTADDYFRGGGRVPGWAAGVSV
FATTLSSITFMSIPAKAYTSDWTFIIGQYLAIAILPLVFYFYIPFFRKLK
ITSAYEYLEARFDVRSRLFASLSFMLFHIGRVAIITYLTVLALRPFMGID
PVVLIVLISLLCIIYTWMGGIEGVIWTDVIQGLLLSGGAVLIFIMICFKV
DGGISEIFTTTAQADKFFPTTQWRWSWTDSTIPVLMIGFLFANIQQFTAS
QDVVQRYIVTDSIKETKRTLITNAKLVAIIPIFFFAIGSALFVYYQQNPS
LLPAGFNTGGILPLFIVTEMPIGIAGLIIAAIFAAAQSSISSSLNSISSC
FNSDIYTRLSKSSPSPEQKMKVAKLVIIVAGIFSSLAAIWLVLSDWDAFN
SLIGLMGGPMTGLFMLGIFVKRANAGSAVVGIIVSIIAVLAARYGSDLNF
FFYGVIGSMSVVIAGTITAPLFAPAKQLSL
3D structure
PDB5nv9 Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+site.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NA A A56 T57 L59 S60 A339 S342 S343 A52 T53 L55 S56 A335 S338 S339
BS02 NA A V178 D182 S342 S345 S346 V174 D178 S338 S341 S342
BS03 SLB A T58 S60 I62 T63 G81 Q82 R135 F243 T54 S56 I58 T59 G77 Q78 R131 F239
Gene Ontology
Molecular Function
GO:0015293 symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:5nv9, PDBe:5nv9, PDBj:5nv9
PDBsum5nv9
PubMed29717135
UniProtB4EZY7|SIAT_PROMH Sodium/sialic acid symporter SiaT (Gene Name=siaT)

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