Structure of PDB 5nud Chain A

Receptor sequence
>5nudA (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPLDPLWEFPRDRLVLGKPLGEGGQVVRAEAFGMDPARPDQASTVAVKM
LKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAA
KGNLREFLRARRPPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVL
VTEDNVMKIADFGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLG
GSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTF
KQLVEALDKVLLAVSEE
3D structure
PDB5nud Approaches to selective fibroblast growth factor receptor 4 inhibition through targeting the ATP-pocket middle-hinge region.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D612 R616 N617 D630
Catalytic site (residue number reindexed from 1) D143 R147 N148 D161
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 99K A L473 R483 V550 E551 C552 A553 A554 L619 L21 R29 V96 E97 C98 A99 A100 L150 PDBbind-CN: -logKd/Ki=7.49,Kd=32nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5nud, PDBe:5nud, PDBj:5nud
PDBsum5nud
PubMed30108871
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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