Structure of PDB 5nu3 Chain A

Receptor sequence
>5nu3A (length=119) Species: 9606 (Homo sapiens) [Search protein sequence]
SMRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDI
VKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFC
SKLAEVFEQEIDPVMQSLG
3D structure
PDB5nu3 Beyond the BET Family: Targeting CBP/p300 with 4-Acyl Pyrroles.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 99E A P1110 F1111 V1115 L1120 Y1125 Y1167 N1168 R1173 V1174 P32 F33 V37 L42 Y47 Y89 N90 R95 V96 MOAD: Kd=0.23uM
PDBbind-CN: -logKd/Ki=6.64,Kd=0.23uM
BS02 BU3 A Q1104 D1105 Q26 D27
BS03 BU3 A R1173 F1177 R95 F99
BS04 BU3 A K1141 Q1146 Q1152 K63 Q68 Q74
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5nu3, PDBe:5nu3, PDBj:5nu3
PDBsum5nu3
PubMed28766825
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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