Structure of PDB 5ntw Chain A

Receptor sequence
>5ntwA (length=245) Species: 9606 (Homo sapiens) [Search protein sequence]
YASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSM
WEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLV
RMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFS
EDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLSKTHRQSIL
AKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFST
3D structure
PDB5ntw Structural States of ROR gamma t: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds.
ChainA
Resolution1.64 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K336 Q346 Q349 I350 P500 L501 E504 K73 Q83 Q86 I87 P237 L238 E241
BS02 peptide A I492 Q495 I229 Q232
BS03 98N A Q286 L287 W317 C320 R364 M365 R367 A368 F377 F378 F388 L396 I400 H479 Q23 L24 W54 C57 R101 M102 R104 A105 F114 F115 F125 L133 I137 H216 MOAD: ic50=0.6nM
PDBbind-CN: -logKd/Ki=9.22,IC50=0.6nM
BindingDB: IC50=<100nM,Ki=<100nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:5ntw, PDBe:5ntw, PDBj:5ntw
PDBsum5ntw
PubMed28590087
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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