Structure of PDB 5ntt Chain A

Receptor sequence
>5nttA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
ENLYFQSMSVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEA
DNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMEYGNIDLN
SWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGML
KLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSKISPKSDVWSL
GCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKC
CLKRDPKQRISIPELLAHPYVQIQTHP
3D structure
PDB5ntt Understanding inhibitor resistance in Mps1 kinase through novel biophysical assays and structures.
ChainA
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D647 K649 N652 D664 D674 T686
Catalytic site (residue number reindexed from 1) D137 K139 N142 D154 D164 T176
Enzyme Commision number 2.7.12.1: dual-specificity kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SVE A I531 S537 A551 K553 M602 Y604 G605 N606 D608 S611 L654 I663 I21 S27 A41 K43 M92 Y94 G95 N96 D98 S101 L144 I153 PDBbind-CN: -logKd/Ki=5.75,Kd=1764nM
BindingDB: IC50=182nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ntt, PDBe:5ntt, PDBj:5ntt
PDBsum5ntt
PubMed28726638
UniProtP33981|TTK_HUMAN Dual specificity protein kinase TTK (Gene Name=TTK)

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