Structure of PDB 5nqe Chain A

Receptor sequence
>5nqeA (length=180) Species: 9606 (Homo sapiens) [Search protein sequence]
MKQQNFCVVELLPSDPEYNTVASKFNQTCSHFRIEKIERIQNPDLWNSYQ
AKKKTMDAKNGQTMNEKQLFHGTDAGSVPHVNRNGFNRGKGTYFAVNANY
SANDTYSRPDANGRKHVYYVRVLTGIYTHGNHSLIVPPSKNPQNPTDLYD
TVTDNVHHPSLFVAFYDYQAYPEYLITFRK
3D structure
PDB5nqe Design and synthesis of potent inhibitors of the mono(ADP-ribosyl)transferase, PARP14.
ChainA
Resolution2.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 94Z A H1682 G1683 Y1714 F1715 A1716 Y1721 S1722 Y1727 G1751 N1752 H1753 T1774 L1782 H71 G72 Y93 F94 A95 Y100 S101 Y106 G130 N131 H132 T153 L161 PDBbind-CN: -logKd/Ki=6.15,IC50=0.70uM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5nqe, PDBe:5nqe, PDBj:5nqe
PDBsum5nqe
PubMed28495083
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

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