Structure of PDB 5nps Chain A

Receptor sequence
>5npsA (length=693) Species: 9606 (Homo sapiens) [Search protein sequence]
PTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQ
QGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQ
INPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCL
QIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAI
AERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHL
MQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGK
AADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALF
MDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDF
IYDNRIVLNGIDLKAFLDSLPDVKIVKMLNMPVIPMNTIAEAVIEMINRG
QIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAIV
YCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQNM
GLPNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTPMV
TMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKKVR
GKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMI
3D structure
PDB5nps Thio-Linked UDP-Peptide Conjugates as O-GlcNAc Transferase Inhibitors.
ChainA
Resolution1.68 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H496 N557 P559 T633 K634 H183 N244 P246 T320 K321
BS02 94T A H496 P559 T633 Q839 K842 L866 V895 A896 K898 H901 H920 T921 T922 D925 H183 P246 T320 Q506 K509 L533 V561 A562 K564 H567 H586 T587 T588 D591 PDBbind-CN: -logKd/Ki=5.89,Ki=1.3uM
External links
PDB RCSB:5nps, PDBe:5nps, PDBj:5nps
PDBsum5nps
PubMed29723473
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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