Structure of PDB 5npc Chain A

Receptor sequence
>5npcA (length=780) Species: 155077 (Cellvibrio japonicus) [Search protein sequence]
AVFYKEHKLRNDGLVITTNQGNIRLQFKSEAAIEVLYRADSKQLPSFALA
QPESAIKAQLTETENHLQFSGGTLTARIQKRPFAISYYRDSELLLAEESG
FQVKINFRFYLSPGEKILGGGQRILGMDRRGQRFPLYNRAHYGYSDHSGQ
MYFGLPAIMSSKQYILVFDNSASGAMDIGKTESDILQLEAKSGRSAYILV
AGNSYPSLIENFTQVTGRQPLPPRWALGSFASRFGYRSEAETRATVQKYK
TEDFPLDTIVLDLYWFGKDIKGHMGNLDWDKENFPTPLDMMADFKQQGVK
TVLITEPFVLTSSKRWDDAVKAKALAKDPQGQPKAFELYFGNGGIIDVFS
KEGSRWFSSIYKDLSKQGVAGWWGNLGEPEMHPEDTQHAIGDADTVHNAY
GHRWAEMLYQQQLDQFPELRPFIMMRAGFVGSQRYGMIPWTGDVSRTWGG
LASQVELALQMSLLGFGYIHSDLGGFADGETLDKEMYIRWLQYGVFQPVY
RPHGQDHIPSEPVFQDEETKAILRPLVKLRYRMLPYIYTAAYQNTLTGMP
LMRPLFFSDEKNPALIDNKTSYFWGDSLLVTPITQAGVESVSIPAPKGVW
FDFWKDTRYQTDGAPLTLPTDLHTIPVLVKAGAFMPYVPAVSTTEDYRSD
SLEIHYYADASVPLAQGEIFEDDGKDPNSIKRNQFDLLTLQATHTDNQLH
FQLARTGKGYRGMPERRATTLVIHNASDQYQHLDINGKTIAIAQADCAST
PALACYDQERRQLQLVFTWGREALNLRLHK
3D structure
PDB5npc 1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor.
ChainA
Resolution1.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.161: oligosaccharide 4-alpha-D-glucosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A R58 R231 R24 R194
BS02 SO4 A T732 N734 Q735 T695 N697 Q698
BS03 SO4 A T97 N99 H100 T63 N65 H66
BS04 SO4 A R753 R808 E809 R716 R771 E772
BS05 SO4 A G239 N240 N248 G202 N203 N211
BS06 94E A F271 D299 W410 N412 R463 D480 F513 H540 F234 D262 W373 N375 R426 D443 F476 H503 PDBbind-CN: -logKd/Ki=4.00,IC50>100uM
BS07 OXL A S764 K817 S727 K780
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0016757 glycosyltransferase activity
GO:0030246 carbohydrate binding
GO:0033825 oligosaccharide 4-alpha-D-glucosyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:5npc, PDBe:5npc, PDBj:5npc
PDBsum5npc
PubMed28776021
UniProtB3PEE6|OL4AG_CELJU Oligosaccharide 4-alpha-D-glucosyltransferase (Gene Name=agd31B)

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