Structure of PDB 5nkb Chain A

Receptor sequence
>5nkbA (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
TTEIHPSCVTRQKVIGAGEFGEVYKGMLKKEVPVAIKTLKAGYTEKQRVD
FLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREKDG
EFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSDFG
LSRVLEDDPEATYTTGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVM
TYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARR
PKFADIVSILDKLIRAPDSLKTLADFDPRVSIRLP
3D structure
PDB5nkb Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChainA
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D739 A741 R743 N744 D757 D766 P780
Catalytic site (residue number reindexed from 1) D130 A132 R134 N135 D148 D157 P169
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8ZT A I619 A644 K646 E663 I690 T692 M695 E696 G698 L746 S756 I15 A35 K37 E54 I81 T83 M86 E87 G89 L137 S147 MOAD: Kd=0.759nM
PDBbind-CN: -logKd/Ki=9.12,Kd=0.76nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5nkb, PDBe:5nkb, PDBj:5nkb
PDBsum5nkb
PubMed28544567
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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