Structure of PDB 5nk5 Chain A

Receptor sequence
>5nk5A (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
TTEIHPSCVTRQKVIGFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQR
VDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFLREK
DGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSNLVCKVSD
FGLSRVLEDDPEATYTTGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMW
EVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQER
ARRPKFADIVSILDKLIRAPDSLKTLADFDPVSIRLP
3D structure
PDB5nk5 Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors.
ChainA
Resolution1.329 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D739 A741 R743 N744 D757 D766 P780
Catalytic site (residue number reindexed from 1) D132 A134 R136 N137 D150 D159 P172
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 90K A I619 A644 I645 K646 I690 T692 M695 E696 G698 L746 I15 A37 I38 K39 I83 T85 M88 E89 G91 L139
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5nk5, PDBe:5nk5, PDBj:5nk5
PDBsum5nk5
PubMed28544567
UniProtP29317|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)

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