Structure of PDB 5nib Chain A

Receptor sequence
>5nibA (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
ENLYFQGASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTG
YQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGA
MEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSL
SALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKT
HRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
GG
3D structure
PDB5nib Potent and Orally Bioavailable Inverse Agonists of ROR gamma t Resulting from Structure-Based Design.
ChainA
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K336 Q346 I350 P500 L501 E504 K79 Q89 I93 P243 L244 E247
BS02 8Y5 A Q286 L287 C320 H323 L324 M358 R364 M365 R367 A368 F377 F378 F388 L391 I397 I400 F401 H479 Q29 L30 C63 H66 L67 M101 R107 M108 R110 A111 F120 F121 F131 L134 I140 I143 F144 H222 MOAD: ic50=0.019uM
PDBbind-CN: -logKd/Ki=7.72,IC50=0.019uM
BindingDB: IC50=19nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5nib, PDBe:5nib, PDBj:5nib
PDBsum5nib
PubMed30095900
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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