Structure of PDB 5ni8 Chain A

Receptor sequence
>5ni8A (length=252) Species: 9606 (Homo sapiens) [Search protein sequence]
ENLYFQGASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTG
YQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGA
MEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSL
SALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKT
HRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFS
GG
3D structure
PDB5ni8 Potent and Orally Bioavailable Inverse Agonists of ROR gamma t Resulting from Structure-Based Design.
ChainA
Resolution1.94 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K336 Q346 I350 L501 E504 K79 Q89 I93 L244 E247
BS02 8Y2 A Q286 L287 C320 H323 R364 M365 R367 A368 F377 F378 F388 I400 F401 Q29 L30 C63 H66 R107 M108 R110 A111 F120 F121 F131 I143 F144 MOAD: ic50=0.02uM
PDBbind-CN: -logKd/Ki=7.70,IC50=0.02uM
BindingDB: IC50=20nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ni8, PDBe:5ni8, PDBj:5ni8
PDBsum5ni8
PubMed30095900
UniProtP51449|RORG_HUMAN Nuclear receptor ROR-gamma (Gene Name=RORC)

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