Structure of PDB 5nhz Chain A

Receptor sequence
>5nhzA (length=230) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
EYPTVSEIPVGEVRLYQIADGVWSHIATQSFDGAVYPSNGLIVRDGDELL
LIDTAWGAKNTAALLAEIEKQIGLPVTRAVSTHFHDDRVGGVDVLRAAGV
ATYASPSTRRLAEVEGNEIPTHSLEGLSSSGDAVRFGPVELFYPGAAHST
DNLVVYVPSASVLYGGCAIYELSRTSAGNVADADLAEWPTSIERIQQHYP
EAQFVIPGHGLPGGLDLLKHTTNVVKAHTN
3D structure
PDB5nhz Metallo-beta-lactamase inhibitors by bioisosteric replacement: Preparation, activity and binding.
ChainA
Resolution1.85 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H116 H118 D120 H196 C221 Y224 N233 H263
Catalytic site (residue number reindexed from 1) H83 H85 D87 H148 C167 Y170 N179 H209
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H116 H118 H196 H83 H85 H148
BS02 ZN A D120 C221 H263 D87 C167 H209
BS03 8XZ A Y67 W87 D120 H196 C221 R228 N233 H263 Y36 W56 D87 H148 C167 R174 N179 H209 MOAD: ic50=4.7uM
PDBbind-CN: -logKd/Ki=5.33,IC50=4.7uM
BindingDB: IC50=4700nM
External links