Structure of PDB 5ng2 Chain A

Receptor sequence
>5ng2A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
AICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTP
LLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLN
ELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHNLKTQNILL
DNEFHVKIADFGLSKWRMMGTIIYMPPENYEPSIKHDIYSYAVITWEVLS
RKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWA
QNPDERPSFLKCLIELEPVLRTFE
3D structure
PDB5ng2 Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N146 K148 Q150 N151 D164 T189
Catalytic site (residue number reindexed from 1) N142 K144 Q146 N147 D160 T171
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A S25 V32 A45 K47 Y97 M98 S102 Q150 L153 S21 V28 A41 K43 Y93 M94 S98 Q146 L149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5ng2, PDBe:5ng2, PDBj:5ng2
PDBsum5ng2
PubMed28545134
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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