Structure of PDB 5ng0 Chain A

Receptor sequence
>5ng0A (length=274) Species: 9606 (Homo sapiens) [Search protein sequence]
ICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPL
LDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNE
LLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLD
NEFHVKIADFGLSKWRMGTIIYMPPENYEPSIKHDIYSYAVITWEVLSRK
QPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQN
PDERPSFLKCLIELEPVFRTFEEI
3D structure
PDB5ng0 Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D146 K148 Q150 N151 D164 T189
Catalytic site (residue number reindexed from 1) D141 K143 Q145 N146 D159 T169
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A V32 A45 K47 M98 L153 D164 V27 A40 K42 M93 L148 D159
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5ng0, PDBe:5ng0, PDBj:5ng0
PDBsum5ng0
PubMed28545134
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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