Structure of PDB 5nfy Chain A

Receptor sequence
>5nfyA (length=512) Species: 229992 (SARS coronavirus Frankfurt 1) [Search protein sequence]
NVTGLFKDCSKIITGLHPTQAPTHLSVDIKFKTEGLCVDIPGIPKDMTYR
RLISMMGFKMNYQVNGYPNMFITREEAIRHVRAWIGFDVEGCHATRDAVG
TNLPLQLGFSTGVNLVAVPTGYVDTENNTEFTRVNAKPPPGDQFKHLIPL
MYKGLPWNVVRIKIVQMLSDTLKGLSDRVVFVLWAHGFELTSMKYFVKIG
PERTCCLCDKRATCFSTSSDTYACWNHSVGFDYVYNPFMIDVQQWGFTGN
LQSNHDQHCQVHGNAHVASCDAIMTRCLAVHECFVKRVDWSVEYPIIGDE
LRVNSACRKVQHMVVKSALLADKFPVLHDIGNPKAIKCVPQAEVEWKFYD
AQPCSDKAYKIEELFYSYAIHHDKFTDGVCLFWNCNVDRYPANAIVCRFD
TRVLSNLNLPGCDGGSLYVNKHAFHTPAFDKSAFTNLKQLPFFYYSDSPC
EYVPLKSATCITRCNLGGAVCRHHANEYRQYLDAYNMMISAGFSLWIYKQ
FDTYNLWNTFTR
3D structure
PDB5nfy Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA.
ChainA
Resolution3.382 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C207 C226 H229 C205 C224 H227
BS02 ZN A H257 C261 H264 C279 H255 C259 H262 C277
BS03 ZN A C477 C484 H487 C464 C471 H474
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004532 RNA exonuclease activity
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5nfy, PDBe:5nfy, PDBj:5nfy
PDBsum5nfy
PubMed29279395
UniProtQ1T6X8

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