Structure of PDB 5nft Chain A

Receptor sequence
>5nftA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
TPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNMLGGRQMIAAVKWA
KAIPGFRNLHLDDQMTLLQYSWMSLMAFALGWRSYRQSSANLLCFAPDLI
INEQRMTLPDMYDQCKHMLYVSSELHRLQVSYEEYLCMKTLLLLSSVPKD
GLKSQALFDEIRMTYIKELGKAIVKREGNSSQNSQRFYQLTKLLDSMHEV
VENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQ
3D structure
PDB5nft Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.
ChainA
Resolution2.3 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 R585 L589 M593 Q597 E751 M752 E755 N759 V47 K51 R57 L61 M65 Q69 E223 M224 E227 N231
BS02 8W8 A M560 L563 N564 L566 G567 Q570 M604 A607 L608 R611 F623 Q642 Y735 C736 T739 M32 L35 N36 L38 G39 Q42 M76 A79 L80 R83 F95 Q114 Y207 C208 T211 BindingDB: IC50=0.900000nM
External links
PDB RCSB:5nft, PDBe:5nft, PDBj:5nft
PDBsum5nft
PubMed28937774
UniProtP04150|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)

[Back to BioLiP]