Structure of PDB 5ncg Chain A

Receptor sequence
>5ncgA (length=113) Species: 9606 (Homo sapiens) [Search protein sequence]
GSMSEQSICQARAAVMVYDDANKKWVPAGGSTGFSRVHIYHHTGNNTFRV
VGRKIQDHQVVINCAIPKGLKYNQATQTFHQWRDARQVYGLNFGSKEDAN
VFASAMMHALEVL
3D structure
PDB5ncg Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
ChainA
Resolution1.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8TB A M14 Y16 W23 N71 F77 Q79 W80 R81 V86 M16 Y18 W25 N73 F79 Q81 W82 R83 V88
BS02 8TB A S0 M1 E3 Q4 Y38 R47 S2 M3 E5 Q6 Y40 R49
BS03 8TB A V58 V59 R84 Q85 Y87 V60 V61 R86 Q87 Y89
External links
PDB RCSB:5ncg, PDBe:5ncg, PDBj:5ncg
PDBsum5ncg
PubMed33184177
UniProtQ8N8S7|ENAH_HUMAN Protein enabled homolog (Gene Name=ENAH)

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