Structure of PDB 5nbs Chain A

Receptor sequence
>5nbsA (length=842) Species: 367110 (Neurospora crassa OR74A) [Search protein sequence]
SLAYSEPHYPSPWMDPKAIGWEEAYEKAKAFVSQLTLLEKVNLTTGIGWG
AEQCVGQTGAIPRLGLKSMCMQDAPLAIRGTDYNSVFPAGVTTAATFDRG
LMYKRGYALGQEAKGKGVTVLLGPVAGPLGRAPEGGRNWEGFSTDPVLTG
IAMAETIKGTQDAGVVACAKHFIGNEQEHFRQVGESQDYGYNISETLSSN
IDDKTMHEMYLWPFVDAIRAGVGSFMCAYTQANNSYSCQNSKLLNNLLKQ
ENGFQGFVMSDWQAHHSGVASAAAGLDMSMPGDTMFNSGRSYWGTNLTLA
VLNGTVPQWRIDDMAMRIMAAFFKVGQTVEDQEPINFSFWTLDTYGPLHW
AARKDYQQINWHVNVQGDHGSLIREIAARGTVLLKNTGSLPLKKPKFLAV
IGEDAGPNPLGPNGCADNRCNNGTLGIGWGSGTGNFPYLVTPDQALQARA
VQDGSRYESVLRNHAPTEIKALVSQQDATAIVFVNANSGEGFIEIDGNKG
DRLNLTLWNEGDALVKNVSSWCNNTIVVLHTPGPVLLTEWYDNPNITAIL
WAGMPGQESGNSITDVLYGRVNPSGRTPFTWGATRESYGTDVLYEPNNGN
EAPQLDYTEGVFIDYRHFDKANASVLYEFGFGLSYTTFEYSNLKIEKHQV
GEYTPTTGQTEAAPTFGNFSESVEDYVFPAAEFPYVYQFIYPYLNSTDMS
ASSGDAQYGQTAEEFLPPKANDGSAQPLLRSSGLHHPGGNPALYDIMYTV
TADITNTGKVAGDEVPQLYVSLGGPEDPKVVLRGFDRLRVEPGEKVQFKA
VLTRRDVSSWDTVKQDWVITEYAKKVYVGPSSRKLDLEEVLP
3D structure
PDB5nbs Structural studies of a glycoside hydrolase family 3 beta-glucosidase from the model fungus Neurospora crassa.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.21: beta-glucosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A D370 Q372 D355 Q357
BS02 BMA A T827 V828 T812 V813
BS03 MAN A R745 K829 R730 K814
BS04 MAN A Q254 S282 Q239 S267
BS05 MAN A Q254 F730 L731 P732 Q239 F715 L716 P717
BS06 MAN A S20 P22 S5 P7
BS07 MAN A E210 H281 E195 H266
BS08 MAN A H479 A480 P481 T482 E483 H464 A465 P466 T467 E468
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0008422 beta-glucosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0005975 carbohydrate metabolic process
GO:0009251 glucan catabolic process
GO:0030245 cellulose catabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5nbs, PDBe:5nbs, PDBj:5nbs
PDBsum5nbs
PubMed30511673
UniProtQ7RWP2

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