Structure of PDB 5n9t Chain A

Receptor sequence
>5n9tA (length=357) Species: 9606 (Homo sapiens) [Search protein sequence]
SKKHTGYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKSV
PLALQRVFYELQHSDKPVGTKKLTKSFGWETLDSFMQHDVQELCRVLLDN
VENKMKGTCVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKG
KKNIFESFVDYVAVEQLDGDNKYDAGEHGLQEAEKGVKFLTLPPVLHLQL
MRFMYDPQTDQNIKINDRFEFPEQLPLDEFLQKTDPKDPANYILHAVLVH
SGDNHGGHYVVYLNPKGDGKWCKFDDDVVSRCTKEEAIEHNYGGHDDDLS
VRHCTNAYMLVYIRESKLSEVLQAVTDHDIPQQLVERLQEEKRIEAQKRK
ERQEHHH
3D structure
PDB5n9t Discovery and characterization of highly potent and selective allosteric USP7 inhibitors.
ChainA
Resolution1.73 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 8QQ A Y224 D295 Q297 Q351 L406 M407 R408 F409 K420 H456 N460 H461 Y465 Y514 Y18 D89 Q91 Q145 L200 M201 R202 F203 K214 H250 N254 H255 Y259 Y308 MOAD: ic50=22nM
PDBbind-CN: -logKd/Ki=6.66,IC50=220nM
BindingDB: IC50=22nM
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
Biological Process
GO:0016579 protein deubiquitination

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Molecular Function
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Biological Process
External links
PDB RCSB:5n9t, PDBe:5n9t, PDBj:5n9t
PDBsum5n9t
PubMed29200206
UniProtQ93009|UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (Gene Name=USP7)

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