Structure of PDB 5n8r Chain A

Receptor sequence

>5n8rA (length=849) Species: 7227 (Drosophila melanogaster)

IRLGCNVSAPSGVLERVKELMEDYSRAPDAKFQQQFRHLLSVNFEEFVAE
TKERNADLDWVNPKLDERLQLELGQRQLEENAKKRLEARKKLPTMKYADD
IIQAVRENQVILIVGSTGCGKTTQVPQILLDDAISRGCASSCRIICTQPR
RISAIAIAEWVSYERCESLGNSVGYQIRLESRKARERASITYCTTGVLLQ
QLQSDPLMHNLSVLILDEIHERSVETDLLMGLLKVILPHRPDLKVILMSA
TVREQDFCDYFNNCPMFRIEGVMFPVKMLYLEDVLSKTNYEFQKRMKHEA
MIEPYLRRIRNSYDSRVLDKLRLPESEGCEDIDFIADLVYYICENEPEGA
ILVFLPGYDKISQLYNILDKPKTSKGQRWRDHMAVFPLHSLMQSGEQQAV
FRRPPAGQRKVIISTIIAETSVTIDDVVYVINSGRTKATNYDIETNIQSL
DEVWVTKANTQQRRGRAGRVRPGICYNLFSRAREDRMDDIPTPEILRSKL
ESIILSLKLLHIDDPYRFLQTLINAPNPEAIKMGVELLKRIEALDQTGTL
TPLGMHLAKLPIDPQMGKMILMSALFCCLDPITSAAAALSFKSPFYSPLG
KESRVDEIKRRMARNMRSDHLMVHNTIIAYRDSRYSHAERDFCYKNFLSS
MTLQQLERMKNQFSELLYNYKFLASSNCKDAASNKNSEKIPLLRAIIGAG
LYPNMAHLRKSRRAIHTMATDDGRRVNFHPSSVNSGESGFDSAYFVYFQR
QKSTDLFLLDSTMVFPMALIIFGDGVEAGVTQNTPYLCVAKTYYFKCNRE
TADVVIQLRSNLEKLLLKKALYPAPIEENGYEKQLIKAIELLLSLDERL

3D structure

• PDB: 5n8r Molecular Mechanistic Insights into Drosophila DHX36-Mediated G-Quadruplex Unfolding: A Structure-Based Model.
• Chain: A
• Resolution: 2.2 Å

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R211 R212 R239 T255 G257 V258 Q261 Q264 S265 G431 Y432 H463 S464 L465 T489 I491 S495 K511 T513 L524 P635 I636 D680 R793 H809 P810 S833 T834	R150 R151 R178 T194 G196 V197 Q200 Q203 S204 G357 Y358 H389 S390 L391 T415 I417 S421 K437 T439 L450 P561 I562 D606 R713 H729 P730 S753 T754

Gene Ontology

Molecular Function

• GO:0002151 G-quadruplex RNA binding
• GO:0003676 nucleic acid binding
• GO:0003678 DNA helicase activity
• GO:0003723 RNA binding
• GO:0003724 RNA helicase activity
• GO:0004386 helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity
• GO:0051880 G-quadruplex DNA binding

Biological Process

• GO:0032508 DNA duplex unwinding
• GO:0044806 G-quadruplex DNA unwinding

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm

External links

• PDB: RCSB:5n8r, PDBe:5n8r, PDBj:5n8r
• PDBsum: 5n8r
• PubMed: 29429875
• UniProt: Q8SWT2