Structure of PDB 5n8m Chain A

Receptor sequence

>5n8mA (length=155) Species: 9606 (Homo sapiens) [Search protein sequence]

GGSLPSIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNF
TFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGCNPVGALQELVVQKG
WRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKML
LRVHT

3D structure

PDB

5n8m Structural basis of siRNA recognition by TRBP double-stranded RNA binding domains.

Chain

Resolution

N/A

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	E37 T40 A57 P60 F62 S79 K80 N159 V161 L175 A187 H188 K211 K214 R215	E25 T28 A45 P48 F50 S67 K68 N87 V89 L103 A115 H116 K139 K142 R143
BS02	rna	A	T30 I32 S33 Q36 A57 K81 K84 Q165 E166 V169 A187 F192 T208 S209 K210	T18 I20 S21 Q24 A45 K69 K72 Q93 E94 V97 A115 F120 T136 S137 K138

External links

PDB	RCSB:5n8m, PDBe:5n8m, PDBj:5n8m
PDBsum	5n8m
PubMed	29449323
UniProt	Q15633\|TRBP2_HUMAN RISC-loading complex subunit TARBP2 (Gene Name=TARBP2)

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